Failure of prophylactic zinc in Wilson disease.
نویسندگان
چکیده
Early institution of prophylactic therapy of asymptomatic Wilson disease patients can prevent the expression of the disease. Zinc is currently preferred therapy for presymptomatic patients. We report onset of symptomatic disease in a presymptomatic patient and deterioration of biochemical parameters in another, despite appropriate zinc therapy.
منابع مشابه
Molecular diagnosis and prophylactic therapy for presymptomatic Chinese patients with Wilson disease.
BACKGROUND The potential for therapy for Wilson disease (WD) emphasizes the importance of presymptomatic diagnosis in families with WD (WD families). OBJECTIVES To investigate the feasibility of presymptomatic DNA diagnosis and evaluate the efficacy of zinc sulfate therapy in WD families. METHODS Seventy-eight clinically unaffected siblings were studied from 51 unrelated WD families that we...
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عنوان ژورنال:
- Indian pediatrics
دوره 45 2 شماره
صفحات -
تاریخ انتشار 2008